EDUCATION

Prof. Jolles trained in Immunology and Allergy at the Royal Free Hospital and Great Ormond Street Hospital in London, the John Radcliffe in Oxford and Westmead Hospital in Sydney. His PhD in Cellular Immunology at NIMR, Mill Hill was on Langerhans cell migration and he has a particular interest in the use of immunoglobulin and its mechanism of action both in primary immunodeficiency and at high dose as an immunomodulator..

EXPERIENCE
Prof. Jolles is Consultant Clinical Immunologist and Honorary Senior Lecturer at the University Hospital for Wales and is Clinical Lead in the Immunodeficiency Centre for Wales and Co-Director the Hub Immunology Diagnostic Laboratory for Wales..

AREAS OF INTEREST

Prof. Jolles’ research interests include investigator initiated studies and clinical trials, commercial studies into new therapeutic products, alongside studies to improve the laboratory diagnosis and management of primary and secondary immunodeficiency and allergy.

RESEARCH OVERVIEW

Recent studies have focused on the development of new screening strategies for antibody deficiency which forms the largest group of primary immunodeficiency (PID) patients aimed at reducing diagnostic delay and associated morbidity. This work has led to the national introduction of screening for antibody deficiency across Wales. Laboratory studies are aimed at improving diagnostic tools, and the development of accredited molecular testing for PID diseases.